Where and How to Inject Testosterone?
For decades, most men have injected their testosterone intramuscularly (IM), primarily into the glutes, quads, or deltoids, using a 1 to 1.5-inch syringe. During the past five years, many men have also begun injecting testosterone subcutaneously (SubQ), a shallow injection into the fat layer on the abdominal or other areas– just under the skin but before reaching muscle. Many TRT patients find SubQ injections less bothersome than IM injections as they require a smaller needle in both length and gauge. SubQ injections are also associated with less irritation that can occur for some men with IM injections. While some men may find IM injections to leave a little soreness at the injected site, SubQ injections are cause no noticeable pain or irritation.
What is the Best Way to Inject Testosterone?
While subcutaneous injections of testosterone are by far the most uncomplicated and most comfortable, the more critical question for any TRT patient is how effective this method is and how it affects potential adverse side effects of TRT? A recent study from the Department of Urology at the University of California (UC) has provided us such answers.
Two hundred thirty-two men took part in the UC study. Baseline levels were recorded for all men in each of the four measurement areas, and then again at 6-12 weeks post-treatment. The results showed that men who underwent SubQ injections of testosterone resulted in a 14% greater increase in total testosterone levels than the testosterone level of IM patients. SubQ patients also resulted in a 41% lower hematocrit post-therapy than IM patients and 26.5% lower E2 levels. For both groups of men, there were no elevated levels of PSA.
References:
Comparison of Outcomes for Hypogonadal Men Treated with Intramuscular Testosterone Cypionate versus Subcutaneous Testosterone Enanthate SIU Academy. Choi E. 10/10/20; 309864; BSP-06.01
Subcutaneous Injection of Testosterone Is an Effective and Preferred Alternative to Intramuscular Injection: Demonstration in Female-to-Male Transgender Patients
The Journal of Clinical Endocrinology & Metabolism, Volume 102, Issue 7, 1 July 2017, Pages 2349–2355
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